Axoguard Nerve Protector®

Axoguard Nerve Protector is the only small intestine submucosa (SIS) implant designed to protect injured and compressed nerves up to 40 mm.

Barrier to soft tissue attachments1

protector innovations

  • Provides a protective barrier to separate the nerve from the surrounding tissues.1
  • Minimizes the potential for soft tissue attachments to allow the nerve to glide.1
  • Vascularizes and remodels into the patient’s own tissue.1
  • Available in a variety of lengths and diameters for intra-operative versatility.

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the importance of biomaterials

In a pre-clinical study conducted to evaluate host tissue response, porcine small intestine submucosa (SIS, Axoguard Nerve Connector) performed significantly better than cross-linked bovine collagen type I (CLC, Integra NeuraGen®) in all outcomes and categories.

Specifically, the study provided evidence that SIS had increased levels of M2 (pro-healing) macrophages which are indicative of a remodeling response, while CLC had increased levels of M1 (pro-inflammatory) macrophages indicative of a chronic inflammatory response.2,3

M1 and M2 Macrophage Distribution

Host Response


U.S. market leader*

in off-the-shelf nerve reconstruction solutions.

6 mos

to remodel into protective layer.1

remodels and vascularizes

to minimize potential for soft tissue attachments.

indications for use

INDICATIONS FOR USE: Axoguard Nerve Protector is indicated for the repair of peripheral nerve injuries where there is no gap. The device is supplied sterile and is intended for one-time use.

CONTRAINDICATIONS: This device is derived from porcine source and should not be used for patients with known sensitivity to porcine material.


ordering information

Code Dimensions
AG0220 2 mm x 20 mm
AG0320 3.5 mm x 20 mm
AG0520 5 mm x 20 mm
AG0720 7 mm x 20 mm
AG1020 10 mm x 20 mm
Code Dimensions
AG0340 3.5 mm x 40 mm
AG0540 5 mm x 40 mm
AG0740 7 mm x 40 mm
AG1040 10 mm x 40 mm

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  1. Kokkalis ZT, et al. Assessment of processed porcine extracellular matrix as a protective barrier in a rabbit nerve wrap model. J Reconstr Microsurg. Jan 2011;27(1):19-28.
  2. Weigert A, et al. Redox-signals and macrophage biology. Mol Aspects Med. Oct 2018;63:70-87.
  3. Zhukauskas R, et al. A comparative study of porcine small intestine submucosa and cross-linked bovine type I collagen as a nerve conduit. J Hand Surg Glob Online. Jul 2021; in press.