our clinical research

Axogen invests in and supports clinical studies and programs to further the understanding and outcomes of peripheral nerve repair.

case studies

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axogen clinical bibliography

Nerve repair solutions are extensively studied. The bibliography contains publications across a variety of nerve repair solutions. Axogen is providing this bibliography for awareness and educational purposes. New publications are added continuously.
The bibliography does not claim to be complete.

ongoing clinical studies

the RANGER® study

A multicenter, retrospective study of Avance® Nerve Graft utilization, evaluations and outcomes in peripheral nerve injury repair (RANGER). The RANGER study, the Avance Nerve Graft registry, has completed the second data milestone and continues to enroll.

the REPOSE-XL study

The REPOSE-XL study is a multicenter, prospective single cohort pilot study intended to evaluate the use of Axoguard Nerve Cap® in large diameter sizes to protect and preserve terminated nerve ends after limb trauma or amputation to optimize subsequent reconstructive procedures. This study is supported, in part, with funding by a grant from the United States Department of Defense peer reviewed Orthopedic Research Program. This study is actively enrolling.

the RECON study

A Multicenter, Prospective, Randomized, Subject and Evaluator Blinded Comparative Study of Nerve Cuffs and Avance® Nerve Graft Evaluating Recovery Outcomes for the Repair of Nerve Discontinuities (RECON), is a Phase 3 clinical trial developed under a Special Protocol Assessment to support the transition of Avance to a licensed biologic. Enrollment and subject follow-up are completed

the MATCH® study

A contemporary cohort control for the RANGER study, MATCH provides outcomes data for nerve autograft and manufactured conduit repairs from participating registry centers. MATCH data milestones have been presented and the cohorts are actively enrolling.


A prospective randomized controlled study to assess the impact of Axoguard Nerve Cap® in the management of painful neuroma as compared to standard neurectomy. REPOSE is actively enrolling.


Sensation Neurotization Outcomes for Women, or Sensation-NOW, is an arm of the RANGER study focused on the breast neurotization procedure and the impact of restoration of sensory function. Sensation-NOW is actively enrolling.

Rethink Pain

Rethink Pain is an observational registry study that will evaluate the patient’s healthcare journey and pain history through detailed medical history and record review. For patients who undergo surgical treatment for pain, the registry will capture standardized outcomes measures to assess key factors such as post-operative pain, pain medication usage, quality of life outcomes, and functional outcome of associated nerves as compared to pre-operative levels. This study is actively enrolling.

learn more

To find out more about our research programs contact us at MedicalAffairs@axogeninc.com.